This chapter contains sections titled: References Further Reading.

This volume presents, in a critical edition, the last part (Books VII-X) of the compilation of Greek commentaries on Aristotle's Nicomachean Ethics together with the corresponding text of the ethics itself, in the Latin translation of Robert Grosseteste, bishop of Lincoln (+1253), the first part of which (Books I-VI) appeared in 1973. Thanks to this translation the composite Commentary had a great impact on the scholastic interpretation of the Ethics, as is witnessed by the works of Albert the Great and (...) John Buridan. The Latin text also contributes to an improvement of the Greek text of the Commentary, for it offers a more complete and a less corrupted version than the Greek manuscripts. (shrink)

v. 1. Eustratius on Book I and the anonymous scholia on Books II, III, and IV. Critical ed. with an introductory study / by H. Paul F. Mercken.

Behavior, language, development, identity, and science—all of these phenomena are commonly characterized as 'social' in nature. But what does it mean to be 'social'? Is there any intrinsic 'mark' of the social shared by these phenomena? In the first book to shed light on this foundational question, twelve distinguished philosophers and social scientists from several disciplines debate the mark of the social. Their varied answers will be of interest to sociologists, anthropologists, philosophers, psychologists, and anyone interested in the theoretical foundations (...) of the social sciences. (shrink)

Environmental philosophy – broadly conceived as using philosophical tools to develop ideas related to environmental issues – is conducted and practised in highly diverse ways in different contexts and traditions in Asia. ‘Asian environmental philosophy’ can be understood to include Asian traditions of thought as well as grassroots perspectives on environmental issues in Asia. Environmental issues have sensitive political facets tied to who has the legitimacy to decide about how natural resources are used. Because of this, the works, practices, and (...) researchers in Asian environmental philosophy are exposed to being (mis)used by diverse stakeholders and actors to support political ends not related to environmental sustainability. Two processes are at play at the nexus of the construction of identities in relation to conceptualisations of nature: eco-orientalism and ecological nationalisms. This paper analyzes and exemplifies these dynamics through a conceptual framework that distinguishes ideological and socio-technical explanations of environmental degradation. Finally, to minimise the risks of political misuse, five pathways are presented to carefully help curate environmental, philosophical statements: contextualise, quantify uncertainty and ‘uniqueness’, downscale, confront claims with local realities and literature, and collaborate with researchers from other disciplines. Conjointly, these pathways aim at favouring intercultural collaboration while valuing diversity, thus supporting the development and exchanges in environmental philosophy in Asia and beyond. (shrink)

The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

The excellent quality and depth of the various essays make [the book] an invaluable resource....It is likely to become essential reading in its field.—CHOICE.

Air pollution is a current concern of people and government entities. Therefore, in urban scenarios, its monitoring and subsequent analysis is a remarkable and challenging issue due mainly to the variability of polluting-related factors. For this reason, the present work shows the development of a wireless sensor network that, through machine learning techniques, can be classified into three different types of environments: high pollution levels, medium pollution and no noticeable contamination into the Ibarra City. To achieve this goal, signal smoothing (...) stages, prototype selection, feature analysis and a comparison of classification algorithms are performed. As relevant results, there is a classification performance of 95% with a significant noisy data reduction. (shrink)

Book reviewed in this article: Mystical Bedlam: Madness, Anxiety, and Healing in Seventeenth Century England. By Michael MacDonald. Making It Crazy: An Ethnography of Psychiatric Clients in an American Community. By Sue E. Estroff. Mind, Mood, and Medicine: A Guide to the New Biopsychiatry. By Paul H. Wender, M.D. and Donald F. Klein, M.D.

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

This compact and somewhat dense study seeks to probe several root ideas in Tillich’s thought, in the conviction that Tillich "is pre-eminent as ‘healer’ of rankling modern wounds—mental, moral, spiritual." In pursuing his aim, Professor Anderson views Tillich ironically, though not uncritically, from the standpoint of existential Thomism. Five pairs of ideas in Tillich’s thought provide the outline of the book. Symbol and faith as ultimate concern: "Tillichian symbols are objectively grounded analogies, revalatory of aspects of reality otherwise opaque to (...) us." Faith, a total act "wherein all the elements of one’s personality are ’synthesized’ and ‘transcended'," is expressible only in terms of revelatory analogies. The philosophy-theology duality: Both philosophy and theology are concerned with the meaning of Being, but they differ in three ways: philosophy probes the meaning of Being in itself, while theology considers its meaning for us; the attitude of the philosopher is intellectually detached, whereas that of the theologian is "personally committed in virtue of loving concern"; the content expressed by philosophy is "intelligible structure," whereas that of theology is "spiritual significance." Tillich’s conception of the philosophy of religion is dealt with in this context. Reason and Revelation: Ontological reason is a faculty for apprehending actual existence; technical reason is concerned with discovering means for ends. The divorce of these two functions of reason during the last one hundred years has been disastrous. By giving a truth which is both certain and of ultimate concern, revelation can reconcile the conflicts which reason experiences. Revelation is the unveiling of man’s personal ultimate concern in terms of symbols and myths. Anything can be the conveyor of revelation, since every being participates in Being-itself. Being and God: Being-itself is the Ground of Being, the Power of Being, the ineffable God. Though no thinker can avoid making God an object of knowledge, God transcends the subject-object structure. Being and Love: For Tillich, life is "being in actuality," and "love is the moving power of life," "the drive towards the unity of the separated." The highest form of love is agape, love of persons, and above all of God, for their own sake. All of this is well-trodden ground. However, Professor Anderson’s synthesis is careful, and his critical remarks are often helpful. His emphasis on the pervasiveness of love in Tillich’s understanding of being, reason, and faith, adds a dimension to which other commentators have paid less attention.—H. F. (shrink)

Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

In this scholarly study, the author, a professor of theology at the University of Iowa, argues that Tillich's thought sought an answer to the problem posed by the questions: "What certainty is left for thought after men have become conscious that thinking itself is historical? If thinking is historically conditioned, can ontological thought ever achieve objective certainty and can theological thought ever achieve religious certainty?" Scharlemann endeavors to show that Tillich constructed his answer to these questions "with two basic ideas, (...) that of 'correlation' and that of a 'paradoxical reality and presence'." In the introduction the author establishes the critical terms which he will use to carry out his "constructive analysis." The first chapter sketches the historical development leading up to the question Tillich faced. The subsequent chapters present various contexts and aspects of Tillich's answer. In the final chapter the author indicates certain aspects of Tillich's thought which seem to be unclear or incomplete, certain contradictory motifs, an entirely new systematic structure which would retrace the same ground as did Tillich, but on a different and, the author believes, a more adequate analytic basis. This study will be of interest primarily to those who are already familiar with Tillich's thought. It is particularly thorough in its analysis of Tillich's early works. The author is quite conversant with the literature by and about Tillich and provides a useful bibliography.--H. F. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Self-harm is a potentially lethal symptom of borderline personality disorder (BPD) that often improves with dialectical behavior therapy (DBT). While DBT is effective for reducing self-harm in many patients with BPD, a small but significant number of patients either does not improve in treatment or ends treatment prematurely. Accordingly, it is crucial to identify factors that may prospectively predict which patients are most likely to benefit from and remain in treatment. In the present preliminary study, twenty-nine actively self-harming patients with (...) BPD completed brain-imaging procedures probing activation of the prefrontal cortex during impulse control prior to beginning DBT and after seven months of treatment. Patients that reduced their frequency of self-harm the most over treatment displayed lower levels of neural activation in the bilateral dorsolateral prefrontal cortex prior to beginning treatment, and they showed the greatest increases in activity within this region after seven months of treatment. Prior to starting DBT, treatment non-completers demonstrated greater activation than treatment-completers in the medial prefrontal cortex and right inferior frontal gyrus. Reductions in self-harm over the treatment period were associated with increases in activity in right dorsolateral prefrontal cortex even after accounting for improvements in depression, mania, and BPD symptom severity. These findings suggest that pre-treatment patterns of activation in the prefrontal cortex underlying impulse control may be prospectively associated with improvements in self-harm and treatment attrition for patients with BPD treated with DBT. (shrink)